Ketamine therapy is facilitated in a controlled environment over a series of sessions. Ketamine is extremely versatile and can be administered in a variety of modalities including intravenous, intramuscular, intranasal (spray), lozenge (troche), topically or per-rectum.
During the initial phase of ketamine therapy, sessions will generally be scheduled for 6-treatments. The response will be evaluated throughout and decided whether continuing therapy is warranted or not.
Studies postulate that ketamine imposes anti-depressant effects of glutamate modulation and NMDA receptor antagonism, which affects mTOR, BDNF, AMPAR and VEGF. Thereby mediating synaptic neuroplasticity.